Georg Muffat was born in Megève, Duchy of Savoy (now in France), and was of Scottish descent. He studied in Paris between 1663 and 1669, where his teacher is often assumed to have been Jean Baptiste Lully. This assumption is largely based on the statement "For six years ... I avidly pursued this style which was flowering in Paris at the time under the most famous Jean Baptiste Lully. "This is ambiguous (in all of the languages in which it was printed) as to whether the style was flourishing under Lully, or that Muffat studied under Lully. In any case, the style which the young Muffat learned was unequivocally Lullian and it remains likely that he had at least some contact with the man himself.
After leaving Paris, he became an organist in Molsheim and Sélestat. Later, he studied law in Ingolstadt, afterwards settling in Vienna. He could not get an official appointment, so he travelled to Prague in 1677, then to Salzburg, where he worked for the archbishop for some ten years. In about 1680, he traveled to Italy, there studying the organ with Bernardo Pasquini, a follower of the tradition of Girolamo Frescobaldi; he also met Arcangelo Corelli, whose works he admired very much. From 1690 to his death, he was Kapellmeister to the bishop of Passau.
Georg Muffat should not be confused with his son Gottlieb Muffat, also a successful composer.